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2.4.1 Errors in Genital Differentiation

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2.4.1 Errors in Genital Differentiation

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Title: 2.4.1 Errors in Genital Differentiation
Author: Marsh, Karen; Bruce, Brendan; La Barbera, Andrew R.
Description: GOAL: To describe the control of sexual differentiation and describe the consequences of defective regulatory mechanisms. 2.4 Objective: To explain how genetic males and females with normally functioning gonads can have the genitalia and sex characteristic of the opposite sex. 2.4.1 Error in Genital Differentiation (Photo Gallery)

Male Pseudohermaphroditism
-What are the consequences of deficient androgen synthesis / action on differentiation and development of the male reproductive tract / sex accessory tissues?
-Deficiencies in which steroids biosynthetic enzymes would result in ambiguous external genitalia and male pseudohermaphroditism?
-What are the consequences of deficient testosterone in the fetus / at puberty?
-What is the most common cause of a deficiency of androgen action?
-What are the consequences of deficient androgen action in male and / female?
-What are the consequences during fetal development and at puberty of an inability to convert testosterone to dihydrotestosterone?

Female Pseudohermaphroditism
-Deficiencies of which steroid biosynthetic enzymes in the adrenal cortex result in production of androgens?
-What are the five most common deficiencies of steroids biosynthetic enzymes?
-What are the consequences of exposure to excess androgens on the reproductive tracts and external genitalia of females?
-What are the consequences of steroid biosynthetic enzyme deficiencies on water and electrolyte balance?

Bookmark: http://hdl.handle.net/2374.UC/163
Date: 2008-08-15

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